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Reproductive outcomes due to past exposure to dioxins.
Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, K01-OH-007609, 2007 Nov; :1-33
Exposure to dioxins and dioxin-like compounds has been implicated as a cause for the increasing incidence of infertility, reproductive disorders, and adverse pregnancy outcomes in humans, but substantiating data is scant. With funding from a NIOSH grant and a Fogarty grant for "International Research and Training in Environmental and Occupational Health," we have identified a unique population of chemical plant workers (Khimprom plant) in the city of Ufa, Bashkortostan, Russian Federation, which was involved in the past production of trichlorophenol (TCP), TCP-Cu, 2, 4, 5-T and 2, 4-D. The proposed plant has a history of very high chlorinated compound exposure both through actual work practices and in the plant environment, which was validated by blood levels and environmental monitoring. We conducted a retrospective matched cohort study of reproductive outcomes in 675 Khimprom plants workers, their spouses and their population controls to assess whether exposures to dioxin (TCDD), and other PCDD and PCDF dioxin like congeners (henceforth generally referred to as "dioxin") are associated with increased risks of adverse reproductive outcomes. The cohort involves workers who have some of the highest occupational exposures to TCDD reported to date. About 25 years after the 2,4,5-T herbicide production had ceased, the median TCDD toxic equivalents blood lipid values in these workers was 166.0 ng/kg (ppt), with several TCDD values > 500 ng/kg. By comparison, 11 years after production ceased German workers had a median TCDD level of 55 ppt, and US workers had a median of 233 ppt 15-37 years after exposure. The Khimprom cohort is unique in its high percentage of female workers (40%). The primary hypothesis of the study is that the sex ratio of offspring of Khimprom plant workers exposed to chlorinated phenols, chlorphenoxy acids, and their chlorinated dioxin and dibenzofuran contaminants will be significantly lower (i.e. lower percentage of male births) than that of general population controls, and that these occupational exposures adversely affected reproductive outcomes, such as preterm birth, stillbirth, neonatal death, low birth weight and in utero growth retardation.
Fertility; Reproductive-effects; Reproductive-system-disorders; Reproduction; Dioxins; Pregnancy; Questionnaires; Environmental-contamination; Environmental-exposure; Environmental-pollution; Exposure-assessment; Exposure-levels; Birth-defects; Phenols; Endocrine-system-disorders
Irina Dardynskaia, MD, PhD, University of Illinois at Chicago, School of Public Health, 2121 West Taylor Street, M/C 922, Chicago, IL 60612-7260
Final Grant Report
NTIS Accession No.
Reproductive Outcomes Due to Past Exposure to Dioxins
University of Illinois at Chicago