Pulmonary alveolar proteinosis in workers at an indium processing facility -author's reply.
Cummings-KJ; Kreiss-K; Roggli-VL
Am J Respir Crit Care Med 2010 Aug; 182(4):578-579
Drs. Lison and Delos describe a reexamination of lung sections of rats exposed to indium-tin oxide (ITO). They report that the proteinaceous material noted in the alveolar lumen (1) was PAS-positive, consistent with pulmonary alveolar proteinosis. We agree with them that this new observation provides additional support for our assertion that ITO caused pulmonary alveolar proteinosis in the cases we described (2). Drs. Lison and Delos question the suggestion of an autoimmune mechanism for indium-related pulmonary alveolar proteinosis. We would like to address their comments on this issue.
Tin-oxides; Alveolar-cells; Respiratory-system-disorders; Pulmonary-function; Pulmonary-system; Pulmonary-system-disorders; Airborne-dusts; Antibody-response; Autoimmunity; Immune-reaction; Protein-biochemistry; Proteins; Tissue-disorders; Lung-tissue; Lung-disorders
Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia
American Journal of Respiratory and Critical Care Medicine