Protection of normal brain cells from gamma-irradiation-induced apoptosis by a mitochondria-targeted triphenyl-phosphonium-nitroxide: a possible utility in glioblastoma therapy.
Huang-Z; Jiang-J; Belikova-NA; Stoyanovsky-DA; Kagan-VE; Mintz-AH
J Neuro-Oncol 2010 Oct; 100(1):1-8
Glioblastoma multiforme is the most frequent and aggressive primary brain tumor. A strong rationale to identify innovative approaches to treat these tumors is required since treatment failures result in local recurrences and median survivals range from 9 to 12 months. Glioma cells are reported to have less mitochondrial content compared to adjacent normal brain cells. Based on this difference, we suggest a new strategy, utilizing protection of normal brain cells by mitochondria-targeted electron scavengers and antioxidants-nitroxides-thus allowing for the escalation of the radiation doses. In this paper, we report that a conjugate of nitroxide with a hydrophobic cation, triphenyl-phosphonium (TPEY-Tempo), significantly protected brain endothelial cells from gamma-irradiation-induced apoptosis while radiosensitizing brain tumor cells. Thus, TPEY-Tempo may be a promising adjunct in the treatment of glioblastoma with the potential to not only prolong survival but also to maintain quality of life and reduce treatment toxicity.
Cancer; Brain-tumors; Blastogenesis; Tumors; Survival-rate; Cellular-structures; Medical-treatment; Oncogenic-agents; Chemotherapy; Radiation-therapy; Radiobiology; Cell-alteration; Antioxidants; Nitrogen-oxides; Hydrophobic-bonds; Irradiation;
Author Keywords: Glioblastoma; Mitochondria; Triphenyl-phosphonium conjugated nitroxide; gamma-irradiation; Apoptosis
Arlan H. Mintz, Department of Neurosurgery, University of Pittsburgh, Cancer Pavillion, Shadyside Hospital, 5150 Center Avenue, Suite 430, Pittsburgh, PA 15232, USA
Journal of Neuro-Oncology
University of Pittsburgh at Pittsburgh