Recommendations for medical management of adult lead exposure.
Kosnett-MJ; Wedeen-RP; Rothenberg-SJ; Hipkins-KL; Materna-BL; Schwartz-BS; Hu-H; Woolf-A
Environ Health Perspect 2007 Mar; 115(3):463-471
Research conducted in recent years has increased public health concern about the toxicity of lead at low dose and has supported a reappraisal of the levels of lead exposure that may be safely tolerated in the workplace. In this article, which appears as part of a mini-monograph on adult lead exposure, we summarize a body of published literature that establishes the potential for hypertension, effects on renal function, cognitive dysfunction, and adverse female reproductive outcome in adults with whole-blood lead concentrations < 40 microg/dL. Based on this literature, and our collective experience in evaluating lead-exposed adults, we recommend that individuals be removed from occupational lead exposure if a single blood lead concentration exceeds 30 microg/dL or if two successive blood lead concentrations measured over a 4-week interval are > or = 20 microg/dL. Removal of individuals from lead exposure should be considered to avoid long-term risk to health if exposure control measures over an extended period do not decrease blood lead concentrations to < 10 microg/dL or if selected medical conditions exist that would increase the risk of continued exposure. Recommended medical surveillance for all lead-exposed workers should include quarterly blood lead measurements for individuals with blood lead concentrations between 10 and 19 microg/dL, and semiannual blood lead measurements when sustained blood lead concentrations are < 10 microg/dL. It is advisable for pregnant women to avoid occupational or avocational lead exposure that would result in blood lead concentrations > 5 microg/dL. Chelation may have an adjunctive role in the medical management of highly exposed adults with symptomatic lead intoxication but is not recommended for asymptomatic individuals with low blood lead concentrations.
Lead-absorption; Lead-poisoning; Exposure-limits; Exposure-levels; Exposure-assessment; Women; Men; Humans; Pregnancy; Lactation; Blood-samples; Hypertension; Reproductive-effects; Reproductive-hazards;
Author Keywords: adult lead exposure; blood lead; chelation; medical management; medical surveillance; pregnancy
M. Kosnett, 1630 Welton St., Ste. 300, Denver, CO 80202 USA
Grant; Cooperative Agreement
Environmental Health Perspectives
MD; CA; CO; MA; MI; NJ
Johns Hopkins University