Major rat allergens causing laboratory animal allergies.
Clin Lab Sci 1990 May-Jun; 3(3):219
Occupational allergies can result in lost time at work and a change in position or vocation by the employee. Studies concerning the prevalence of laboratory animal allergies (LAA) have estimated the incidence of LAA among animal care workers to be eleven and thirty per cent. The rat is the most frequently reported cause of LAA (72.2%) and this study identifies the antigenic components of two major sources of rat protein: rat urine and rat epithelia. Four epithelial protein fractions and three urinary protein fractions were identified by column chromatorgaphy. These fractions were determined to have marked antigeneic activity by the radioallergosorbent (RAST) inhibition assay. The results demonstrated that the rat urinary and the rat epithelial extracts had similiar antigenic components but also each had antigenic components unique to itself.
Allergic-reactions; Allergens; Allergies; Laboratory-animals; Laboratories
Clinical Laboratory Science