Cellular and molecular mechanisms of asbestosis.
Mossman-BT; Gilbert-R; Doherty-J; Shatos-MA; Marsh-J; Cutroneo-K
Chest 1986 Mar; 89(3)(Suppl):160S-161S
Occupational and experimental exposure to asbestos is associated with the development of peribronchiolar and interstitial pulmonary fibrosis. Like other asbestosassociated diseases of the respiratory tract (ie, mesothelioma and bronchogenic carcinoma), asbestosis appears to involve alterations in differentiation and proliferation of affected cell types. Whether the disease process involves either an increase in replication of fibroblasts in the lung or an enhanced ability of individual fibroblasts to produce more collagen or both is uncertain. To address this question, we used a combination of in vitro and in vivo approaches.
Asbestos-fibers; Lung-cells; Cell-damage; Cell-cultures; Cytotoxic-effects; Respiratory-system-disorders; In-vitro-studies; Laboratory-animals; Animal-studies; In-vivo-study; Asbestosis
University of Vermont & St Agric College, Burlington, Vermont