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Pesticide metabolism and potential for metabolic interactions.
J Biochem Mol Toxicol 2005 Aug; 19(4):276-277
Studies in whichhuman hepatocytes are exposed to varying concentrations of pesticides indicate that several pesticides are capable of inducing CYP enzymes. Chlorpyrifos, for example, induces isoforms CYP1A1, 1A2, 2B6, and 3A4 to levels five-fold or greater than controls. Permethrin, which was not metabolized in vitro by CYP isoforms, also induced CYP2A6, 2B6, and 3A4 . The implications of the ability of pesticides to induce CYP isoforms in human hepatocytes will require further study; particularly to determine if concentrations necessary for such induction would occur in vivo.
Agricultural-chemicals; Agricultural-workers; Agriculture; Chemical-analysis; Chemical-composition; Chemical-deposition; Chemical-extraction; Chemical-hypersensitivity; Chemical-properties; Chemical-reactions; Chemical-synthesis; Chemical-warfare-agents; Animals; Exposure-assessment; Exposure-levels; Exposure-limits; Exposure-methods; Environmental-contamination; Environmental-exposure; Environmental-factors; Environmental-hazards; Environmental-health; Environmental-health-monitoring; Environmental-pollution; Environmental-protection; Environmental-stress; Epidemiology; Pesticide-industry; Pesticide-residues; Pesticide-strips; Pesticides; Pesticides-and-agricultural-chemicals; Contaminated-food; Humans; Mesothelial-cells; Metabolic-disorders; Metabolic-study; Metabolism; Pharmaceuticals; Pharmacology; Enzymatic-disorders; Enzymatic-effects; Enzyme-activity; Enzyme-complexes; Enzyme-inhibitors; Enzymes; Enzymology; Organo-phosphorus-compounds; Organo-phosphorus-pesticides; Sulfates; Sulfhydryls; Sulfides; Sulfites; Sulfonamides; Sulfonates; Sulfoxides; Sulfur-compounds; Sulfur-oxides; Liver; Liver-cancer; Liver-cells; Liver-damage; Liver-disorders; Liver-enzymes; Liver-function; Liver-microsomal-enzymes; Liver-microsomal-metabolism; Liver-microsomes; Liver-tissue; Liver-tumors; Livestock; Esters
Randy L. Rose, Department of Environmental and Molecular Toxicology, North Carolina State University, Raleigh, NC 27695
Agriculture; Cooperative Agreement
Issue of Publication
Journal of Biochemical and Molecular Toxicology
North Carolina State University, Raleigh, North Carolina