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Toxicology of AHS important chemicals.
J Biochem Mol Toxicol 2005 Jun; 19(3):180-181
The chloroacetamide herbicides, alachlor., acetochlor butachlor and metolachlor. have been associated with cancers at various sites in rodents as follows: acetochlor.nasal epithelium, thyroid, liver; butachlor.stomach; alachlor.nasal epithelium, thyroid, stomach; metolachlor.liver. The DNA reactive intermediates are quinone imines generated by metabolic pathways that involve CYP isoforms as well as arylamidase. However, since the metabolism of these chemicals varies between rodents and humans, it is not clear how these results may be extrapolated to humans. Although little is known about the metabolism of the substituted aromatic herbicides dicamba and pendimethalin in humans or surrogate animals, they are of low acute toxicity tomammalsand not previously known to be carcinogenic. However, early results from the AHS associate these chemicals with lung cancer.
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Ernest Hodgson, Department of Environmental and Molecular Toxicology, North Carolina State University, Raleigh NC 27695, USA
2921-88-2; 63-25-2; 333-41-5
Agriculture; Cooperative Agreement
Issue of Publication
Journal of Biochemical and Molecular Toxicology
North Carolina State University-Raleigh
Page last reviewed: May 5, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division