Oxidative stress in carcinogenesis.
Caldwell-J; Kuempel-ED; Goldstein-BD
Identification of research needs to resolve the carcinogenicity of high-priority IARC Carcinogens. Views and expert opinions of an IARC/NORA expert group meeting, Lyon, France, 30 June - 2 July 2009. Lyon, France: International Agency for Research on Cancer, IARC Technical Publication No. 42. 2010 Jul; 42:213-214
Although several studies in humans have shown associations between biomarkers of oxidative stress and airborne particulate exposures (Han et al., 2005; Risom et al., 2005; Barregard et al., 2007; Valavanidis et al., 2009), evidence is still lacking on the role of oxidative stress in human carcinogenesis (Loft and Møller, 2006). Lack of specificity and need for standardized and validated methods indicate that careful evaluation is needed in considering the use of oxidative stress biomarkers in epidemiological studies. As for any other biomarkers, research is needed to examine the relationship between exposure to toxic agents and oxidative stress biomarkers, and between these biomarkers and risk of cancer, while controlling for the many individual factors that contribute to oxidative stress. Guidelines on standardizing the collection and measurement of oxidative stress biomarkers in humans (Horvath et al., 2005; ATS, 1999) will facilitate their effective use in epidemiological studies of human cancers.
Cancer; Carcinogens; Carcinogenesis; Carcinogenicity; Biomarkers; Environmental-stress; Environmental-exposure; Environmental-hazards; Humans; Oxidative-enzymes; Oxidation; Oxidative-metabolism; Stress; Fatigue; Epidemiology; Exposure-assessment; Exposure-levels; Exposure-limits; Chemical-analysis; Chemical-hypersensitivity
Identification of research needs to resolve the carcinogenicity of high-priority IARC Carcinogens. Views and expert opinions of an IARC/NORA expert group meeting, Lyon, France, 30 June - 2 July 2009