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Organophosphorus chemicals: potent inhibitors of the human metabolism of steroid hormones and xenobiotics.
Drug Metab Rev 2006 38(1-2):149-162
Although it has been known for some time that organophosphate chemicals containing the P = S moiety are irreversible inhibitors of cytochrome P450, this knowledge has not been generally applied to the human metabolism of xenobiotics. Recent studies have demonstrated that organophosphate insecticides containing this moiety are potent inhibitors of the metabolism of both xenobiotics and endogenous substrates by human liver microsomes and by specific human cytochrome P450 isoforms.
Chemical-analysis; Chemical-binding; Chemical-composition; Chemical-hypersensitivity; Chemical-indicators; Chemical-reactions; Chemical-structure; Chemical-synthesis; Chemical-warfare-agents; Exposure-assessment; Exposure-levels; Exposure-limits; Humans; Agricultural-chemicals; Agricultural-workers; Agriculture; Work-analysis; Work-environment; Worker-health; Workplace-monitoring; Workplace-studies; Liver; Liver-damage; Liver-disorders; Liver-enzymes; Liver-function; Liver-tissue; Microbiology; Microchemistry; Microsomal-enzymes; Organic-chemicals; Organo-nitrogen-compounds; Organo-phosphorus-compounds; Organo-phosphorus-pesticides; Insecticide-poisoning; Insecticides; Pesticide-residues; Pesticides; Pesticides-and-agricultural-chemicals; Public-health; Environmental-exposure; Environmental-factors; Environmental-hazards; Environmental-health; Environmental-health-monitoring; Environmental-pollution; Animal-studies; Animals; Health-hazards; Health-protection; Health-standards; Author Keywords: Carbaryl; Chlorpyrifos; Chlorpyrifos oxon; Cytochrome P450 (CYP); DEET; Estradiol; Human CYP isoforms; Human liver microsomes; Organophosphorus insecticides; Permethrin; Testosterone
Ernest Hodgson, Department of Environmental and Molecular Toxicology, Box 7633, North Carolina State University, Raleigh, NC 27695, USA
Agriculture; Cooperative Agreement
Issue of Publication
Drug Metabolism Reviews
North Carolina State University-Raleigh