Association between IL-1A single nucleotide polymorphisms and chronic beryllium disease and beryllium sensitization.
McCanlies-EC; Yucesoy-B; Mnatsakanova-A; Slaven-E; Andrew-M; Frye-BL; Schuler-CR; Kreiss-K; Weston-A
J Occup Environ Med 2010 Jul; 52(7):680-684
Objective: To determine if single nucleotide polymorphisms (SNPs) in interleukin (IL) IL-1A, IL-1B, IL-1RN, IL-2, IL-9, and IL-9R were associated with chronic beryllium disease (CBD) and beryllium sensitization (BeS). Methods: Forty SNPs in six IL genes were evaluated in 85 individuals with CBD, 61 individuals with BeS, and 730 individuals without BeS or CBD (nonsensitized) using a 5' nuclease polymerase chain reaction assay. Logistic regression was used to evaluate the association between IL SNPs, CBD, and BeS, adjusting for plant-site and HLA-DPB1(Glu69) in additive, dominant, and recessive inheritance models. Results: IL-1A-1142, IL-1A-3769, and IL-1A-4697 were significantly associated with CBD in both the additive and dominant models compared to individuals with BeS or the nonsensitized. Conclusions: These results indicate that genetic variations in the IL-1A gene may play a role in the development of CBD but not BeS.
Biochemical-analysis; Biochemistry; Biohazards; Biological-effects; Biological-factors; Cell-alteration; Cell-biology; Cell-morphology; Cellular-reactions; Chemical-hypersensitivity; Chemical-reactions; Chemical-synthesis; Exposure-assessment; Exposure-levels; Genes; Genetic-factors
Erin McCanlies, PhD, National Institute for Occupational Safety and Health (NIOSH), Centers for Disease Control and Prevention (CDC), Health Effects Laboratory Division, MS-L4050, 1095 Willowdale Road, MS2027, Morgantown, WV 26505
Journal of Occupational and Environmental Medicine