Identification of research needs to resolve the carcinogenicity of high-priority IARC carcinogens. Views and expert opinions of an IARC/NORA expert group meeting, Lyon, France, 30 June - 2 July 2009.
Caldwell J; Carreón-Valencia T; DeMarini DM; Fowler BA; Goldstein BD; Hemminki K; Hines CJ; Hopf NB; Husgafvel-Pursiainen K; Kuempel ED; Lewtas J; Lunn R; Lynge E; McElvenny DM; Muhle H; Nakajima T; Robertson LW; Rothman N; Ruder A; Schubauer-Berigan M; Schulte PA; Siemiatycki J; Silverman DT; Smith MT; Sorahan T; Steenland K; Stevens R; Vineis P; Ward EM; Zahm SH; Zeise L
IARC Technical Publication No. 42. Lyon, France: International Agency for Research on Cancer, 2010 Jul; 42:1-239
This is a concerted effort to identify means of reducing the insufficiency of available data for classifying particular agents in the International Agency for Research on Cancer (IARC) system by identifying information needs and gaps and the research to address them for 20 selected agents generally, in IARC categories 2A, 2B, and 3. The purpose was two-fold: (1) identify research needs to address the information needs and gaps for a more definitive classification, and (2) Create a report that will be of value to funding agencies in determining possible projects to support. The selected experts, generally two for each agent (one toxicologist and one epidemiologist), who either had participated in an IARC Monograph working group that addressed a candidate agent or who were knowledgeable about one or more agents, were selected by the planning committee. For each agent, the experts used a systematic approach reviewing the Monograph and the literature published since the Monograph meeting to determine whether potential research gaps and needs still existed, and what research was needed to change the classification. In addition, experts were encouraged to identify research in progress that they were aware of that could possibly affect the gap analysis. For each agent, a common reporting template was used. All templates had the following categories: 1. Summary; 2. Citation for most recent IARC review. 3. Current evaluation; 4. Exposure and biomonitoring; 5. Cancer in humans; 6. Cancer in experimental animals; 7. Mechanisms of carcinogenicity; 8. Research needs and recommendations; 9. Selected relevant publications since IARC review / References The focus of the recommendations was not meant to be a compilation of all useful or interesting research but rather a focus on research that would be critical or important in resolving classification uncertainties. These templates were uploaded and shared among the experts before the meeting, and discussed during the meeting. Afterwards the templates were revised reflecting the discussions in the meetings. The templates vary in length depending on available new cancer research conducted on the carcinogenic agent since the last IARC update. These revised templates are compiled here to make this comprehensive technical report. The results of this meeting are published in this extensive technical report published by IARC, and in summary format as an article in the Environmental Health Perspectives.
Cancer; Carcinogens; Carcinogenesis; Carcinogenicity; Lead-compounds; Cobalt-compounds; Welding; Ceramic-materials; Diesel-exhausts; Diesel-emissions; Polychlorinated-biphenyls; Shift-work
7439-92-1; 7440-48-4; 11130-73-7; 13463-67-7; 1333-86-4; 100-42-5; 96-09-3; 75-56-9; 50-00-0; 75-07-0; 75-09-2; 79-01-6; 127-18-4; 67-66-3; 117-81-7; 1912-24-9
Agriculture, Forestry and Fishing; Manufacturing
Identification of Research Needs to Resolve the Carcinogenicity of High-priority IARC Carcinogens. Views and Expert Opinions of an IARC/NORA Expert Group Meeting, Lyon, France, 30 June - 2 July 2009, IARC Technical Publication No. 42
OH; NC; GA; WA; IA; MD; CA