Effects of anticholinergic agents on the intestinal absorption of 59Fe ferrous citrate.
Orrego-Matte-H; Fernandez-O; Mena-I
Am J Dig Dis 1971 Sep; 16(9):789-795
The absorption of 59Fe ferrous citrate has been studied in humans after administration of the anticholinergic agent, hexocyclium methosulfate, and in rats, after atropine. In both species, anticholinergics produced a decrease in absorption. The effect of atropine on iron absorption persisted when the radioiron was delivered intragastrically, mixed with gastric juice, but not when administered intraduodenally. Another set of experiments showed that iron absorption decreases when radioiron is intraduodenally delivered in deproteinized acid gastric juice, or in 0.10 N HCl, but not when mixed with neutralized gastric juice. It is concluded that anticholinergic drugs inhibit iron absorption by an effect on a gastric factor necessary for optimal iron absorption, and not through a decrease in acid secretion.
Acids; Biological-effects; Biological-function; Cell-biology; Cellular-reactions; Dietary-effects; Digestive-system; Exposure-assessment; Exposure-levels; Exposure-methods; Gastrointestinal-system; Gastrointestinal-system-disorders; Humans; Iron-compounds; Laboratory-animals; Laboratory-testing; Risk-analysis; Risk-factors; Statistical-analysis
American Journal of Digestive Diseases
Pan American Health Organization, Washington, Dist of Col