In vivo evaluations of transdermal delivery.
Guy-R; Hadgraft-J; Hinz-R; Roskos-K; Bucks-D
Transdermal Controlled Systemic Medication. Chien Y, ed., New York: Mercel Dekker, 1987 Jul; :179-224
The in vivo evaluation of TDD represents a crucial stage in the development of a therapeutic device. Design of the appropriate test experiment and utilization of a relevant experimental system are of fundamental importance, therefore. The objective of this chapter has been to identify methodologies for assessing TDD in vivo and to elucidate the procedures that may prove most informative and indicative of potential success. There have been useful recent advances in the approaches to measure percutaneous absorption in vivo, and these procedures should be given careful attention when planning for TDD evaluation. The advantages and limitations of various animal models are now more clearly defined and, while there remains no "ideal" system, there is now no excuse for choosing a poorly representative species. Finally, our comprehension of the basic physicochemical and biological criteria, which determine the rate of drug passage across the skin, is becoming more sophisticated. We believe that in the foreseeable future it will be increasingly possible to define chemical structure/skin penetration relationships. Hence, we envisage the achievement of reliable predictions of TDD in vivo, from basic physical chemical and pharmacokinetic information.
Pharmaceuticals; Skin-absorption; Pharmacodynamics; Physiological-chemistry; Mathematical-models; Chemical-properties; Physical-properties
Transdermal Controlled Systemic Medication
University of California San Francisco, San Francisco, California