Electrocardiographic changes in neonatal rats exposed prenatally to ethylene glycol monomethyl ether.
Teratology 1987 Apr; 35(2):53A
We previously reported electrocardiographic (EKG) changes in fetuses exposed prenatally to ethylene glycol monomethyl ether (EGME) (Teratology 32, 33-39, 1985). The present findings indicate that the same aberrations persist beyond the neonatal period in rats exposed prenatally to EGME. Pregnant dams were treated by gavage on gestation days 7-13 (sperm = day 1) with 50 or 75 mg/kg EGME in 10 ml/kg distilled water. There were no survivors beyond 3 days of age in the 75 mg/kg EGME group. Treatment with 50 mg/kg EGME did not affect maternal body weight gain, but gestation was prolonged. The number of viable litters and litter size were reduced. Growth of offspring and the number of pups surviving through weaning were also reduced by EGME exposure. EKGs were obtained from unanesthetized and unrestrained rats at four and six weeks of age. About ten percent of EGME exposed offspring exhibited EKG abnormalities. The most prevalent abnormality was a QRS aberration that consisted of a double R or S wave, and suggested an intraventricular conduction delay. The delay was of short duration lasting only two-to-four msec in most cases.
Laboratory-animals; Animal-studies; Animals; Cardiovascular-function; Cardiovascular-system-disorders; In-utero-study; In-utero-studies; In-utero-exposure; Teratology; Teratogenesis; Teratogens