Cigarette smoking and pulmonary diffusing capacity.
Van Ganse WF; Ferris BG Jr.; Cotes JE
Am Rev Respir Dis 1972 Jan; 105(1):30-41
Cigarette smoking caused a reduction in the diffusing capacity of the lungs for carbon monoxide and a reduction in coefficient of diffusion of carbon monoxide. This implies that cigarette smoking should be considered in prediction equations. The reduction in the diffusing capacity appeared to be due to a change in the volume of blood in the capillaries. This could account for some of the reversible changes observed in ex-cigarette smokers. The membrane component changed more with age. Prediction formulas were developed for diffusing capacity for the ratio, diffusing capacity/alveolar volume, based on age, height, and life-time packs smoked.
Age-factors; Biological-effects; Blood-samples; Blood-serum; Cigarette-smoking; Humans; Mathematical-models; Men; Pulmonary-disorders; Pulmonary-function-tests; Pulmonary-system; Pulmonary-system-disorders; Respiration; Respiratory-function-tests; Respiratory-system-disorders; Spirometry; Vital-capacity; Women
American Review of Respiratory Disease
Harvard University, Boston, Massachusetts