Clinical and experimental studies of distal axonopathy -- a frequent form of brain and nerve damage produced by environmental chemical hazards.
Schaumburg HH; Spencer PS
Ann NY Acad Sci 1979 Oct; 329:14-29
This presentation will summarize our clinical and pathological studies of the nervous system degeneration (distal dying-back axonopathy) in man and experimental animals produced by acrylamide monomer and certain hydrocarbon compounds (hexacarbons). "Distal axonopathy" is a term recently introduced to describe those diseases which are expressed as symmetrical, distal, axonal degeneration occurring concurrently in the peripheral nervous system (PNS) and in selected tracts of the central nervous system (CNS). Most of the humans and experimental animals with these conditions initially appear to have peripheral neuropathy. The human distal axonopathies include: (1) many of the naturally occurring, genetically determined, system disorders (spino-cerebellar degenerations), (2) certain nutritional disorders (thiamine deficiency), (3) uremic neuropathy, (4) the neuropathies associated with some malignancies (multiple myeloma), and ( 5 ) the toxic neuropathies induced by industrial chemicals (acrylamide, n-hexane, cresyl phosphate, arsenic, carbon disulfide), and pharmaceutical agents (nitrofuradantoin, isoniazid). Indeed, it now seems likely that distal axonopathy constitutes one of the fundamental and most common histopathological reactions of the mammallian nervous system to exogenous toxins.
NIOSH-Grant; Neurotoxic-effects; Pharmaceutical-chemicals; Toxic-substances; Spinal-cord-disorders; Nervous-system-disorders; Clinical-studies; Laboratory-animals; Animal-studies; Histological-reactions; Neurotoxic-agents; Pathological-studies; Neurophysiological-effects
Pathology Albert Einstein Coll of Med 1300 Morris Park Avenue Bronx, N Y 10461
79-06-1; 110-54-3; 1330-78-5; 7440-38-2; 75-15-0; 130-26-7; 67-20-9; 54-85-3
Neurotoxic Disorders; Neurotoxic-effects
Annals of the New York Academy of Sciences
Yeshiva University, New York, New York