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Applying the modern principles of risk assessment to protect workers: update of the derivation methods for Immediately Dangerous to Life and Health (IDLH) values.
Dotson-G; Parker-A; Maier-A; Haber-L
Toxicologist 2010 Mar; 114(1):381
The ability of airborne contaminants to quickly overwhelm victims has been well demonstrated within occupational settings resulting in acute and chronic irreversible health effects, and even death. Since the 1970s, the National Institute for Occupational Safety and Health (NIOSH) has been tasked with establishing acute exposure guidelines called Immediately Dangerous to Life and Health (IDLH) values to aid in protecting workers from such high risk environments. IDLH values are defined as, "atmospheric concentrations of toxic, corrosive, or asphyxiant substances that, via inhalation exposure, pose an immediate threat to life or would cause immediate or delayed irreversible adverse health effects or would interfere with an individual's ability to escape from a dangerous atmosphere in the event of a respirator failure." NIOSH is in the process of revising the derivation process for IDLH values to ensure that they are sufficiently health protective. The objective of this presentation is to discuss the impact of a refined weight of evidence approach based on the modern principles of risk assessment for the derivation of new and revised IDLH values. The refined approach was applied to 20 case study chemicals; lessons learned from these case studies were used to hone the revised derivation method for IDLH values.
Airborne-particles; Biochemistry; Biological-effects; Chemical-hypersensitivity; Chemical-reactions; Environmental-exposure; Exposure-assessment; Exposure-levels; Exposure-methods; Health-protection; Inhalation-studies; Microbiology; Microchemistry; Microscopic-analysis; Occupational-exposure; Occupational-hazards; Occupational-health; Particulate-dust; Particulates; Respiratory-equipment; Respiratory-infections; Respiratory-irritants; Respiratory-protection; Respiratory-protective-equipment; Risk-analysis; Risk-factors; Statistical-analysis; Toxic-effects; Toxins; Work-areas; Work-environment; Worker-health; Work-operations; Workplace-studies
Issue of Publication
The Toxicologist. Society of Toxicology 49th Annual Meeting and ToxExpo, March 7-11, 2010, Salt Lake City, Utah