Rationale: Chronic rhinosinusitis (CRS) is a major cause of morbidity in North America, However, the etiology remains poorly defined. Hypersensitivity to fungi, in particular Alternaria, has been proposed to have a putative role. In this study, our objective was to characterize skin prick test (SP1) and human serum reactivity to other common aeroallergens in CRS patients. Methods: One hundred and thirty two subjects (18-65 years of age) were recruited into the study. 101 subjects had a confirmed diagnostic history of CRS and 31 subjects were recruited as controls. Enrolled subjects underwent SPT to a panel of perennial, grass, weed, tree, and fungal aeroallergens. A blood sample was collected by venipuncture for hematological analysis. Atopic status to selected common environmental allergens (grass, mold, and tree species) was determined using Phadia ImmunoCap. Specific-lgG was also quantified to Cladosporium herbarum, AIternaria alternate, Stachybotrys atra, and Aspergillus, versicolor. Differences between CRS and control patients were determined by an analysis of variance (ANOVA) and chi-squared analysis. Results: No statistically significant differences were observed between mean specific IgE and IgG titers in CRS and control patients in the ANOVA analysis. Chi-squared analysis of SPT data revealed similar statistically insignificant results, however, positive SPT reactivity to Alternaria was identified as a risk factor for having CRS (OR 3.58, p < 0.0487). Conclusions: Sensitization to common perennial, grass, weed, and tree aeroallergens were not associated with CRS. This study supports recent data which suggests that in predisposed individuals, Alternaria sensitization is associated with increased risk of having CRS.
Journal of Allergy and Clinical Immunology. 2010 American Academy of Allergy, Asthma & Immunology (AAAAI) Annual Meeting New Orleans, Louisiana, February 26-March 2, 2010