NIOSHTIC-2 Publications Search
Exposure to titanium dioxide (TiO2) nanoparticles up-regulates neurotrophin expression in rodent airways.
Scuri-M; Chen-B; Castranova-V; Samsell-L; Walton-C; Piedimonte-G
Abstracts of the American Thoracic Society International Conference, May 15-20, 2009, San Diego, California. New York: American Thoracic Society, 2009 May; :1
Environmental exposure to nanoparticles has been associated with an increased risk of childhood and adult asthma. The neurotrophins nerve growth factor (NGF) and brainderived neurotrophic factor (BDNF) are key regulatory elements of neuronal development and responsiveness and control expression of the genes encoding the precursor of the proinflammatory neurotransmitter substance P (SP) and other neuropeptides in airway sensory neurons. Changes in their expression are associated with neurosensory dysfunctions resulting in bronchoconstriction and airway hyperresponsiveness. In this study, we investigated the expression of NGF, BDNF and their receptors in the lungs of adult (12 wks), weanling (2 wks), and newborn (1-2 days) rats after acute inhalational exposure to titanium dioxide (Ti02) nanoparticles. In adult animals, nanoparticulate exposure did not result in any significant changes in neurotrophin expression. The same burden of exposure, however, caused a 1.4 fold increase in NGF and BDNF expression associated with a 2 fold increase of the BDNF receptor TrKb in weanling rats (p<0.02; n= 10-12), and a 2.8 fold increase in NGF expression associated with a 2 fold increase of NGF low affinity receptor p75 in newborns compared to age-matched controls (p<O.OOI; n= 10-12). The results of this study show for the first time that exposure to nanoparticulate upregulates the expression of lung neurotrophins, and that this effect is age-dependent, indicating the presence of a critical window of vulnerability in earlier stages of lung development which may lead to a higher risk of developing asthma.
Nanotechnology; Particulates; Particulate-dust; Aerosols; Aerosol-particles; Bronchial-asthma; Age-factors; Respiratory-system-disorders; Pulmonary-system-disorders; Lung-disease; Lung-disorders; Author Keywords: Titanium Dioxide; Particles; Nanoparticles; Pulmonary Toxicity; Asthma
Abstracts of the American Thoracic Society International Conference, May 15-20, 2009, San Diego, California