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Analytical methodology and assessment of potential second-hand exposure to fentanyl in the hospital surgical setting.
Law BF; Hettick JM; Hornsby-Myers J; Siegel PD
J Addict Dis 2010 Jan; 29(1):51-58
Second-hand exposure to aerosols containing fentanyl and other opiates during surgical procedures has been implicated as possibly contributing to maintenance of addiction among medical professionals, specifically anesthesiologists. This article outlines a pilot study that was conducted to verify a reported finding fentanyl in the air of operating suites. Environmental fentanyl air sampling and analysis methods were developed and evaluated for this study. Multiple sampling media and extraction solvents were evaluated for trace fentanyl air sampling. Non-specific binding losses were reduced by using silanized binder-free glass fiber sampling media with subsequent methanol extraction. Filtration air samples were then collected in surgical suites during the entire operation time from two cardiovascular surgical procedures. Both surgical procedures were conducted at the same hospital but on different days. Samples were extracted and analyzed by high-performance liquid chromatography/tandem mass spectrometry using a capillary high-performance liquid chromatography coupled to a quadrupole time-of-flight mass spectrometer. The total air volume collected per surgery was 290 to 300 L at a rate of 1 LPM giving an limit of quantification for fentanyl of 57 pg/m3 air (17 pg/filter). No fentanyl was detected in the air during cardiovascular surgical operations from either surgical suite.
Air-quality-measurement; Air-sampling-techniques; Exposure-assessment; Exposure-levels; Exposure-methods; Indoor-environmental-quality; Occupational-exposure; Operating-rooms; Qualitative-analysis; Sampling; Sampling-equipment; Sampling-methods; Author Keywords: Fentanyl; second-hand; air sampling; surgical
Brandon F. Law, MS, National Institute for Occupational Safety and Health, Allergy and Clinical Immunology Branch, Health Effects Laboratory Division,1095 Willowdale Rd., MS 4020, Morgantown, WV 26505
Issue of Publication
Journal of Addictive Diseases
Page last reviewed: May 8, 2020Content source: National Institute for Occupational Safety and Health Education and Information Division