Association between fine particulate matter and oxidative DNA damage may be modified in individuals with hypertension.
Kim-JY; Prouty-LA; Fang-SC; Rodrigues-EG; Magari-SR; Modest-GA; Christiani-DC
J Occup Environ Med 2009 Oct; 51(10):1158-1166
OBJECTIVE: To investigate the association between particulate matter (PM2.5) and urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) in hypertensive and non-hypertensive individuals. METHODS: Twelve hypertensives and nine non-hypertensives were monitored during a 36-hour period using a repeated-measures panel study design. Personal exposure to PM2.5 was assessed using a real-time continuous monitor. Spot urine samples collected at 12-hour intervals were analyzed for 8-OHdG. RESULTS: Exposure to PM2.5 was associated with a decrease in 8-OHdG in hypertensives compared with an increase in non-hypertensives, after adjusting for age, gender, smoking status, and time of day. CONCLUSIONS: The results suggest modification of the association between PM2.5 exposure and urinary 8-OHdG by hypertension status. Antioxidant activity present in antihypertensive medications may play a role or PM2.5 exposure may reduce the capacity to repair DNA damage in hypertensives. These results should be confirmed with further investigation.
Particulates; Statistical-analysis; Humans; Hypertension; Biomarkers
David C. Christiani, MD, Harvard School of Public Health, 665 Huntington Ave., Boston, MA 02115
Journal of Occupational and Environmental Medicine
Harvard School of Public Health