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Association between fine particulate matter and oxidative DNA damage may be modified in individuals with hypertension.
Kim JY; Prouty LA; Fang SC; Rodrigues EG; Magari SR; Modest GA; Christiani DC
J Occup Environ Med 2009 Oct; 51(10):1158-1166
OBJECTIVE: To investigate the association between particulate matter (PM2.5) and urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) in hypertensive and non-hypertensive individuals. METHODS: Twelve hypertensives and nine non-hypertensives were monitored during a 36-hour period using a repeated-measures panel study design. Personal exposure to PM2.5 was assessed using a real-time continuous monitor. Spot urine samples collected at 12-hour intervals were analyzed for 8-OHdG. RESULTS: Exposure to PM2.5 was associated with a decrease in 8-OHdG in hypertensives compared with an increase in non-hypertensives, after adjusting for age, gender, smoking status, and time of day. CONCLUSIONS: The results suggest modification of the association between PM2.5 exposure and urinary 8-OHdG by hypertension status. Antioxidant activity present in antihypertensive medications may play a role or PM2.5 exposure may reduce the capacity to repair DNA damage in hypertensives. These results should be confirmed with further investigation.
Particulates; Statistical-analysis; Humans; Hypertension; Biomarkers
David C. Christiani, MD, Harvard School of Public Health, 665 Huntington Ave., Boston, MA 02115
Issue of Publication
Journal of Occupational and Environmental Medicine
Harvard School of Public Health
Page last reviewed: May 8, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division