Whole-body inhalation exposure to 1-bromopropane suppresses the IgM response to sheep red blood cells in female B6C3F1 mice and Fisher 344/N rats.
Anderson-SE; Munson-AE; Butterworth-LF; Germolec-D; Morgan-DL; Roycroft-JA; Dill-J; Meade-BJ
Inhal Toxicol 2010 Feb; 22(2):125-132
1-Bromopropane (1-BP) is categorized as a high-production-volume chemical and is currently used in the manufacture of pharmaceuticals, pesticides, and other chemicals. Its usage is estimated to be around 5 million pounds per year, resulting in the potential for widespread exposure in the workplace. Case reports and animal studies have suggested exposure to this compound may cause adverse reproductive and neurological effects. Using a battery of immunological assays, the immunotoxicity of 1-BP after whole body inhalation exposure in both mice and rats was evaluated. Significant decreases in the spleen immunoglobulin (Ig) M response to sheep red blood cells (SRBC) were observed in both mice (125-500ppm) and rats (1000ppm) after exposure to 1-BP for 10wk. In addition, total spleen cells and T cells were significantly decreased after approximately 4wk of 1-BP exposure in both mice (125-500ppm) and rats (1000ppm). No change in natural killer (NK) cell activity was observed. The observed alterations in spleen cellularity, phenotypic subsets, and impairment of humoral immune function across species raise further concern about human exposure to 1-BP and demonstrate the need for additional investigations into potential adverse health effects.
Laboratory-animals; Animal-studies; Animals; Immune-reaction; Immunoglobulins; Immunology; Inhalation-studies
Stacey E. Anderson, PhD, National Institute for Occupational Safety and Health (NIOSH), 1095 Willowdale Drive, Morgantown, WV 26505, USA
Healthcare and Social Assistance; Services