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Chemical warfare agent degradation products: HPLC-MS analysis.
Encyclopedia of Chromatography, 3rd Edition. Cazes J, ed., Boca Raton, FL: Taylor and Francis, 2009 Oct; 1:386-395
High-performance liquid chromatography-mass spectrometry (HPLC-MS) has become a commonly used analytical technique for the analysis of chemical warfare agent (CWA) degradation products. This area of research has gained greater importance in recent years. Most CWAs are not persistent and degrade in the open environment. The degradation products are usually polar or ionic; thus, HPLC is considered an ideal separation technique. MS detection offers a sensitive and specific means for quantitative analysis for these compounds. Some of the common designs and strategies of HPLC-MS are discussed as well as the common analytical challenges. Also, specific examples of HPLC-MS applications involving screening procedures are reviewed and described. These procedures utilized both reversed-phase and ion-pair reversed-phase HPLC to separate several alkyl methylphosphonic acids, which are the degradation products of nerve agents.
Analytical-chemistry; Analytical-processes; Chemical-warfare-agents; Liquid-chromatography; Mass-spectrometry; Author Keywords: HPLC-MS; Sarin; VX; mustard gas
Book or book chapter
Encyclopedia of Chromatography, 3rd Edition
Page last reviewed: May 8, 2020Content source: National Institute for Occupational Safety and Health Education and Information Division