Excessive longitudinal FEV1 decline and risks to future health: a case-control study.
Wang-ML; Avashia-BH; Wood-J; Petsonk-EL
Am J Ind Med 2009 Dec; 52(12):909-915
Background: Accelerated loss of forced expiratory volume in 1 s (FEV1) in an individual is considered an indicator of developing lung disease. Methods: We investigated longitudinal FEV1 slopes, calculated by simple linear regression, and adverse health outcomes after 10-30 years, among 1,428 chemical plant workers. Cases were defined by FEV1 slopes below 5th percentile values for the cohort. Cases were matched with controls (107 pairs) for race, gender, smoking status, year of birth, age, height, and calendar year at first test. Matched pair statistics were used for comparisons. Results: Cases had a higher proportion, compared to controls, of diagnosis of COPD or emphysema (17.8% vs. 1.9%, P¼0.0002), medication use for respiratory diseases (24.3% vs. 4.7%, P<0.0001), dyspnea (15% vs. 3.7%, P¼0.0042), and wheezing or rhonchi on examination (10.3% vs. 1.9%, P¼0.0225). Conclusions: Chemical plant workers who experienced accelerated FEV1 declines experienced four to nine times as many adverse health conditions over 10-30 years.
Case-studies; Chemical-factory-workers; Chemical-industry-workers; Chemical-manufacturing-industry; Demographic-characteristics; Exposure-assessment; Exposure-levels; Exposure-methods; Health-hazards; Humans; Inhalation-studies; Lung-function; Occupational-exposure; Occupational-hazards; Occupational-health; Occupational-respiratory-disease; Pulmonary-disorders; Pulmonary-function; Pulmonary-function-tests; Pulmonary-system-disorders; Respiratory-function-tests; Respiratory-irritants; Respiratory-system-disorders; Statistical-analysis; Work-environment; Worker-health; Workplace-studies; Surveillance;
Author Keywords: spirometry; pulmonary disease; chronic obstructive; mass screening; excessive FEV1 decline
Edward L. Petsonk, Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Mail Stop H-G900-2,1095 Willowdale Road, Morgantown, WV 26505
American Journal of Industrial Medicine