High dietary antioxidant intakes are associated with decreased chromosome translocation frequency in airline pilots.
Yong-LC; Petersen-MR; Sigurdson-AJ; Sampson-LA; Ward-EM
Am J Clin Nutr 2009 Nov; 90(5):1402-1410
Background: Dietary antioxidants may protect against DNA damage induced by endogenous and exogenous sources, including ionizing radiation (IR), but data from IR-exposed human populations are limited. Objective: The objective was to examine the association between the frequency of chromosome translocations, as a biomarker of cumulative DNA damage, and intakes of vitamins C and E and carotenoids in 82 male airline pilots. Design: Dietary intakes were estimated by using a self-administered semiquantitative food-frequency questionnaire. Translocations were scored by using fluorescence in situ hybridization with whole chromosome paints. Negative binomial regression was used to estimate rate ratios and 95% CIs, adjusted for potential confounders. Results: Significant and inverse associations were observed between translocation frequency and intakes of vitamin C, beta-carotene, beta-cryptoxanthin, and lutein-zeaxanthin from food (P < 0.05). Translocation frequency was not associated with the intake of vitamin E, alpha-carotene, or lycopene from food; total vitamin C or E from food and supplements; or vitamin C or E or multivitamin supplements. The adjusted rate ratios ( 95% CI) for >= median compared with, = median compared with, median combined intakes of vitamins C and E, beta- carotene, beta-cryptoxanthin, and lutein-zeaxanthin from food: 0.27 (0.14, 0.55). Conclusion: High combined intakes of vitamins C and E, beta- carotene, beta-cryptoxanthin, and lutein-zeaxanthin from food, or a diet high in their food sources, may protect against cumulative DNA damage in IR-exposed persons.
Aircrews; Biological-function; Biomarkers; Exposure-assessment; Exposure-levels; Exposure-limits; Exposure-methods; Mathematical-models; Occupational-exposure; Pilots; Questionnaires; Risk-factors; Statistical-analysis; Vitamins
Lee C Yong, Industrywide Studies Branch, Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, R-15, Cincinnati, OH 45226
Transportation, Warehousing and Utilities
The American Journal of Clinical Nutrition