Measurement of methamphetamine on surfaces using surface plasmon resonance.
Smith-JP; Martin-A; Sammons-DL; Striley-C; Biagini-R; Quinn-J; Cope-R; Snawder-JE
Toxicol Mech Methods 2009 Jul-Sep; 19(6-7):416-421
Field methods are needed to assess the contamination of surfaces by methamphetamine from illicit drug manu facturing. This study performed a feasibility study on the use of a surface plasmon resonance (SPR) based instrument (SensiQ Discovery) in the evaluation of surface contamination by methamphetamine. The main goal was to see if the method could be sensitive enough for field measurements. A competitive immunochemical assay was developed for the instrument which was able to measure methamphetamine at 9 ng/ml with a range of 9-250 ng/ml. Methamphetamine was spiked onto ceramic tiles and the assay was able to detect methamphet amine contamination at 25 ng/100 cm(2), which is below the 50 ng/100 cm(2) standard used for surface cleanup assessment. The instrument is compact and mobile and is sensitive enough for use for measurement of meth amphetamine on surfaces, so it is a candidate for a field method for methamphetamine surface contamination. Its use for this application will require further development of the instrument to make it more convenient to use. Also further evaluation of ruggedness and use of the instrument under various environmental conditions such as temperature and humidity are needed to define conditions under which the instrument can be employed in field measurements.
Chemical-cleaning; Chemical-hypersensitivity; Chemical-processing; Environmental-exposure; Environmental-factors; Exposure-assessment; Exposure-methods; Immune-reaction; Immunochemistry; Physiological-chemistry; Physiological-factors; Physiological-response; Standards; Surface-properties
Jerome P. Smith, Biomonitoring Research Team, Biomonitoring and Health Assessment Branch, National Institute for Occupational Safety and Health, Cincinnati, OH 45226
Toxicology Mechanisms and Methods