Purpose: To evaluate associations between parental occupational exposure and autism spectrum disorder (ASD). Methods: Complete occupational, exposure, and diagnosis data were available for 228 children (93 ASD, 135 control children) and their parents enrolled in the Childhood Autism Risks from Genetics and Environment study. Three industrial hygienists (IHs) independently assessed potential occupational exposure based on the parents' listed occupation and responsibilities. Prevalence of self-reported and IHassessed exposures for mothers and fathers was calculated. Odds ratios and 95% confidence intervals were used to assess associations. Results: When the presence of exposure in at least one parent was evaluated, self-reported exposure to asphalt was positively associated with ASD (p = 0.029). Although not statistically significant, ASD was also at least twice as likely in children who had at least one parent exposed to disinfectants, solvents, phenol, styrene, lacquers and varnish. Conclusion: These results suggest that occupational exposures to some volatile chemicals may be important to consider in the etiology of ASD.
Biochemical-analysis; Biohazards; Biological-effects; Biological-factors; Biological-function; Biological-monitoring; Chemical-hypersensitivity; Chemical-indicators; Chemical-properties; Children; Cleaning-compounds; Exposure-assessment; Exposure-levels; Exposure-methods; Neurological-system; Occupational-exposure; Occupational-hazards; Painting; Risk-analysis; Risk-factors; Solvents; Statistical-analysis; Toxic-effects; Workplace-studies