Uptake of materials from the nasal cavity into the blood and brain: are we finally beginning to understand these processes at the molecular level?
Genter-MB; Kendig-EL; Knutson-MD
Ann NY Acad Sci 2009 Jul; 1170:623-628
Substances that enter the nasal cavity can access the bloodstream or central nervous system by processes including receptor cell uptake, transneuronal transport, and paracellular transport. Until recently, the molecular mechanisms by which agents move from the nasal cavity have not been described. Although the full complement of transporter proteins found in the nasal cavity has certainly not yet been identified, several recent observations have advanced this field substantially. We summarize here a representative sample of transporter proteins found in olfactory mucosa and/or nasal respiratory mucosa and the substrates that they transport into the brain and/or bloodstream.
Biohazards; Biological-effects; Biological-function; Biological-monitoring; Biological-systems; Biological-transport; Blood-stream; Cell-function; Cell-metabolism; Cellular-function; Cellular-reactions; Cellular-transport-mechanism; Cellular-uptake; Cerebrovascular-system; Inhalants; Inhalation-studies; Molecular-biology; Mucous-membranes; Nasal-cavity; Neuropathology; Neurophysiological-effects; Neurophysiology; Neurotoxic-effects; Neurotoxicology; Neurotransmitters; Neurotransmitters; Olfactory-disorders; Respiratory-hypersensitivity; Respiratory-irritants; Respiratory-system-disorders;
Author Keywords: ZIP8; ZIP14; DMT1; transporters; paracellular transport; olfactory; nasal; solute carriers
Mary Beth Genter, PhD, DABT, Department of Environmental Health, ML 670056, 144 Kettering Lab, University of Cincinnati, Cincinnati, OH 45267-0056
Annals of the New York Academy of Sciences, International Symposium on Olfaction and Taste
University of Cincinnati