Changes in fluid balance hormones in rhesus-monkeys during cold-air exposure.
Meyer-LG; Saxton-JL; Lotz-WG
FASEB J 1995 Mar; 9(4)(II):A646
We previously observed that young male primates did not exhibit diuresis during an acute exposure to cold air. To determine the cause of the antidiuretic effect, we investigated the hormones associated with body fluid shifts during acute cold air exposure. Five adult male rhesus monkeys (Macaca mulatta) (5-8 kg) were studied. Plasma vasopressin, aldosterone, and norepinephrine were measured before, during, and after a 2-h test period at 6 and 26 degree C. Plasma hormone concentrations and urine volume were measured every 30 min during each test. The monkeys did not exhibit diuresis during the first 90 min of cold exposure, but urine volume increased over the last 30 min of exposure and remained elevated during recovery. Plasma vasopressin, aldosterone, and norepinephrine increased significantly during exposure, but the vasopressin concentration decreased notably during the last 30 min of cold when the urine volume was elevated. The data suggest that vasopressin, aldosterone, and epinephrine contribute to the acute antidiuretic response of the rhesus monkey during cold stress and that vasopressin may be the dominant hormone in this occurrence. When extrapolating to human conditions, rhesus monkeys may not be suitable models for studying fluid balance hormones during cold exposure because the immediate response is the opposite of that observed in humans.
Air-flow; Cold-stress; Exposure-assessment; Exposure-methods; Fluid-mechanics; Fluids; Hormone-activity; Hormones; Laboratory-animals; Laboratory-testing
Abstract; Conference/Symposia Proceedings
The FASEB Journal. Experimental Biology 95 - Annual Meeting of Professional Research Scientists, Atlanta, Georgia, April 9-13, 1995