The differential effects of the herbicide Banvel (Dicamba) on peroxisomal and cytochrome P-450 activities.
Espandiari-P; Thomas-VA; Robertson-LW
Toxicologist 1994 Mar; 14(1):388
The widely used broad leaf herbicide Banvel is similar in structure to xenobiotics which induce hepatic drug metabolism or proliferation of hepatic peroxisomes. The ability of xenobiotics to effect these hepatic changes often portends their positive outcomes in rodent chronic bioassays. Banvel's ability to induce hepatomegaly, peroxisome proliferation and drug metabolism was studied in male and female Sprague Dawley rats. Rats were placed on feed containing 0.001, 0.01, 0.1, and 1% Banvel or 0.01% ciprofibnate for 3 weeks. Banvel had no effect on relative liver weight or feed efficiency in either female or male rats at all doses tested. Banvel caused a statistically significant increase in peroxisomal B-oxidation in female rats only at 1 % dietary level. Banvel significantly decreased ethoxyresondin O-deethylase activity at several doses while benzoloxyresorufin O-debenzylase activity was increased at the highest dose of Banvel in both female and male rats. Lauric acid hydroxylase activity was increased in microsomes from male rats fed the highest level of Banvel.
Laboratory-testing; Toxins; Toxicology; Toxic-effects; Exposure-assessment; Exposure-levels; Animal-studies; Laboratory-animals; Herbicides; Dietary-effects
The Toxicologist. Society of Toxicology 33rd Annual Meeting, March 13-17, 1994, Dallas, Texas
University of Kentucky, Department of Preventive Medicine, Lexington, KY