Vibration alters serum markers of bone turnover in rats.
Krajnak-K; Johnson-C; Miller-R; Waugh-S
Proceedings of the 4th International Conference on Whole Body Vibration Injuries, June 2 - 4, 2009, Montreal, Canada. Montréal, Québec, Canada: Institut de recherche Robert-Sauvé en santé et en sécurité du travail (IRSST), 2009 Jun; :85-86
After 8 weeks of vibration exposure, osteocalcin was slightly increased in rats exposed to vibration at 125 Hz, indicating that vibration at this frequency stimulated osteoblast activity and bone mineralization. 1. Exposure to vibration at both frequencies also resulted in an increase in CTX-1, a serum marker of bone resorption, indicating that vibration also stimulated osteoclast activity and bone resorption. 2. The ratio of osteocalcin/CTX1 (an index of mineralization to resorption) was significantly lower in rats exposed to vibration than in control rats, suggesting that bone remodelling was altered to favour resorption instead of mineralization. 3. These findings are consistent with in vitro studies demonstrating that vibration induces matrix degradation that can lead to disc degeneration and pain. 4. Exposure to higher frequency, lower magnitude vibration is capable of inducing bone resorption in the absence of mechanical shock.
Vibration; Vibration-effects; Vibration-exposure; Laboratory-animals; Animals; Animal-studies; Skeletal-system-disorders; Skeletal-disorders
Kristine Krajnak, Engineering and Control Techology Branch, National lnstititute for Occupational Safety and Health, 1095 Willowdale Rd, Morgantown, West Virginia 26505, USA
Proceedings of the 4th International Conference on Whole Body Vibration Injuries, June 2 - 4, 2009, Montreal, Canada.