NIOSHTIC-2 Publications Search

Cytochrome c/cardiolipin relations in mitochondria: a kiss of death.

Authors
Kagan VE; Bayir HA; Belikova NA; Kapralov O; Tyurina YY; Tyurin VA; Jiang JF; Stoyanovsky DA; Wipf P; Kochanek PM; Greenberger JS; Pitt B; Shvedova AA; Borisenko G
Source
Free Radic Biol Med 2009 Jun; 46(11):1439-1453
NIOSHTIC No.
20035427
Abstract
Recently, phospholipid peroxidation products gained a reputation as key regulatory molecules and participants in oxidative signaling pathways. During apoptosis, a mitochondria-specific phospholipid, cardiolipin (CL), interacts with cytochrome c (cyt c) to form a peroxidase complex that catalyzes CL oxidation; this process plays a pivotal role in the mitochondrial stage of the execution of the cell death program. This review is focused on redox mechanisms and essential structural features of cyt c's conversion into a CL-specific peroxidase that represent an interesting and maybe still unique example of a functionally significant ligand change in hemoproteins. Furthermore, specific characteristics of CL in mitochondria-its asymmetric transmembrane distribution and mechanisms of collapse, the regulation of its synthesis, remodeling, and fatty acid composition-are given significant consideration. Finally, new concepts in drug discovery based on the design of mitochondria-targeted inhibitors of cyt c/CL peroxidase and CL peroxidation with antiapoptotic effects are presented.
Keywords
Cell-biology; Cell-growth; Cell-metabolism; Cell-morphology; Cellular-reactions; Humans; Oxidative-metabolism; Oxidative-processes; Author Keywords: Cytochrome c; Cardiolipin; Peroxidase; Lipidomics; Oxidative stress; Apoptosis; Autophagy; Mitochondrial targeting; Free radicals
Contact
VE Kagan, Ctr Free Rad & Antioxidant Hlth, Pittsburgh, PA 15219
CODEN
FRBMEH
Publication Date
20090601
Document Type
Journal Article
Email Address
kagan@pitt.edu
Funding Type
Grant
Fiscal Year
2009
Identifying No.
Grant-Number-R01-OH-008282
Issue of Publication
11
ISSN
0891-5849
NIOSH Division
HELD
Source Name
Free Radical Biology and Medicine
State
WV; PA
Performing Organization
University of Pittsburgh at Pittsburgh
Page last reviewed: August 26, 2022
Content source: National Institute for Occupational Safety and Health Education and Information Division