Immunotoxicogenomics: gene expression and immunotoxicology in the age of genomics.
Germolec-DR; Burns-Naas-LA; Gerberick-GF; Ladics-GS; Ryan-CA; Pruett-SB; Yucesoy-B; Luebke-RW
Genomics: fundamentals and applications. Choudhuri S, Carlson DB, eds. New York: Informa HealthCare, 2008 Oct; :247-268
For the near future, genomic arrays are likely to continue to play a role in identifying modes or mechanisms of action and the biochemical pathways that are altered following chemical exposure rather than supplying data appropriate for hazard identification and risk assessment. Additional studies addressing specificity, sensitivity, and reproducibility are needed to determine whether any of the molecular changes observed at a particular time and dose of chemical are predictive of toxicological effects observed in vivo or in vitro . There is no doubt, however, that further development, evaluation, and implementation of gene array technology have the potential to reduce animal usage and ultimately reduce the cost of conducting toxicology studies in general.
Immune-reaction; Immunological-tests; Immunology; Immunotoxins; Genes; Gene-mutation; Risk-analysis; Analytical-processes; Toxic-effects; Toxicopathology
Healthcare and Social Assistance; Services
Genomics: fundamentals and applications