Absorption, distribution, and excretion of [14C]-3-chloro-4-methylaniline hydrochloride in two species of birds following a single oral dose.
Goldade-DA; Tessari-D; Johnston-JJ
J Agric Food Chem. 2004 Dec 29; 52(26):8074-8080
Ring-labeled [14C]-3-chloro-4-methylaniline hydrochloride (250 microg per bird) was delivered to 21 red-winged blackbirds (Agelaius phoeniceus) and 21 dark-eyed juncos (Junco hyemalis) via oral gavage, and the distribution and excretion of radioactivity were determined at 15 and 30 min and 1, 4, 8, 12, and 24 h (n = 3 per time point). Direct measurement of radioactivity as well as measurement following combustion was accomplished using a liquid scintillation counter. Elimination from most tissues followed a two-compartment model, with very rapid elimination occurring between time 0 and 4 h and a much slower elimination phase occurring after that. The average half-life of elimination for the initial phase in most tissues examined was 0.16 h for juncos and 0.62 h for blackbirds. The average for the slower second phase of elimination was 3.4 h for juncos and 5.4 h for blackbirds. The radioactivity in blackbird kidney tissues did not change significantly for the duration of the test, pointing toward the kidney as a possible site of action for this important agricultural chemical.
Chemical-analysis; Chemical-binding; Chemical-composition; Chemical-extraction; Chemical-hypersensitivity; Chemical-indicators; Chemical-structure; Chemical-synthesis; Agricultural-chemicals; Agricultural-workers; Agriculture; Health-hazards; Health-protection; Health-standards; Safety-education; Safety-measures; Safety-monitoring; Safety-personnel; Safety-practices; Safety-programs; Exposure-levels; Exposure-limits; Animal-studies; Animals; Risk-analysis; Risk-factors;
Author Keywords: 3-Chloro-4-methylaniline hydrochloride; CPTH; avicide; disposition; red-winged blackbirds; dark-eyed juncos
Agriculture; Cooperative Agreement
Journal of Agricultural and Food Chemistry
Colorado State University - Fort Collins