Honolulu-Asia Aging Study (HAAS): relationship of organochlorine levels with Parkinson's disease risk.
Ross-W; Pellizzari-E; He-Q; Miller-D; O'Callaghan-JP; Petrovitch-H; Abbott-R; Tanner-C; White-L
Toxicologist 2009 Mar; 108(1):260
The Honolulu Heart Program / Honolulu-Asia Aging study (HAAS) is a community based, long term, prospective study of dementia and Parkinson's disease (PD) in a cohort of 8006 Japanese-American men living on the island of Oahu and born between 1900 and 1919. Interest in the association of neurotoxicants and PD was stimulated by the fact that many of the HAAS participants worked on sugar and pineapple plantations in Hawaii and would have been exposed to numerous agricultural chemicals. In order to further explore the possible relationship of pesticide exposure with PD risk, organochlorine levels were obtained on previously frozen occipital lobe brain samples from 445 cohort decedents. Twenty-one organochlorines were measured using gas chromatography. The presence of incidental Lewy bodies (i.e. found in brains of decedents without a history of PD during life) is thought to represent a preclinical stage of PD in persons who died before the classic motor features of the disease were manifest. New data on the association of brain organochlorine levels with neuropathologically confirmed Parkinson's Disease and with the presence of Lewy bodies in the substantia nigra or locus coeruleus will be presented.
Agricultural-chemicals; Agricultural-processes; Agricultural-workers; Agriculture; Biological-effects; Biological-factors; Disease-incidence; Exposure-assessment; Exposure-levels; Exposure-methods; Genetic-factors; Neurological-reactions; Neurotoxic-effects; Neurotoxicity; Occupational-exposure; Organo-chlorine-compounds; Pesticides-and-agricultural-chemicals; Statistical-analysis
The Toxicologist. Society of Toxicology 48th Annual Meeting and ToxExpo, March 15-19, 2009, Baltimore, Maryland