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Potential cardiovascular effects of fullerene C60 inhalation exposure.
Simeonova-PP; Erdely-A; Liston-A; Luster-MI; Roycroft-J; Germolec-D; Walker-NJ
Toxicologist 2009 Mar; 108(1):50
Fullerenes are forms of carbon nanomaterials used in a wide variety of commercial applications and have the potential for significant human exposure. Based on ambient ultrafine particle research, it is predicted that small particles may have systemic toxicity related to cardiovascular outcomes. This study evaluates the cardiovascular effects of subchronic inhalation exposure of B6C3F1 mice to C60 particles (diameter 1 and 0.05 um). The initial screening for cardiovascular toxicity was conducted applying a custom-designed TaqMan array for genes known to play an important role in the mechanisms of atherosclerosis such as inflammation, oxidative stress, and coagulation. We observed changes on expression of several genes related to stress response, including c-fos, and heat shock protein (hsps) 25, 70, and 90 in the aortas of the exposed mice independent of the size of the particles. These findings were confirmed by a real-time RT-PCR. Hsps are incremental in triggering many autoimmune/chronic inflammatory diseases. In this regard, it has been suggested a multifaceted role for hsps in atherosclerosis. For example, it has been reported that the expression of hsps is upregulated very early at lesion-prone sites in the aortas of young apoE-/- mice. Thus, fullerene exposure of wild type mice, not prone to develop atherosclerosis, resulted in a cardiovascular stress response which may provide a predisposition to atherogenesis. Disclaimer: The findings and conclusions in this abstract are those of the authors and do not necessarily represent the views of the National Institute for Occupational Safety and Health.
Biological-distribution; Biological-effects; Biological-function; Biological-systems; Biological-transport; Breathing; Cardiovascular-system; Cardiovascular-system-disorders; Cardiovascular-disease; Cardiovascular-function; Cardiovascular-system-disease; Exposure-assessment; Exposure-levels; Exposure-methods; Genetic-factors; Immune-reaction; Immune-system; Immune-reaction; Immunologic-disorders; Immunology; Laboratory-animals; Lung-disorders; Lung-irritants; Lung-fibrosis; Lung-function; Particle-aerodynamics; Particulate-dust; Pulmonary-disorders; Pulmonary-function; Respiratory-function-tests; Statistical-analysis; Nanotechnology
Issue of Publication
The Toxicologist. Society of Toxicology 48th Annual Meeting and ToxExpo, March 15-19, 2009, Baltimore, Maryland