Vascular function, inflammation, and variations in cardiac autonomic responses to particulate matter among welders.
Fang-SC; Cavallari-JM; Eisen-EA; Chen-JC; Mittleman-MA; Christiani-DC
Am J Epidemiol 2009 Apr; 169(7):848-856
Patients with health conditions associated with impaired vascular function and inflammation may be more susceptible to the adverse health effects of fine particulate (particulate matter with a mass median aerodynamic diameter of < / = 2.5 mum (PM(2.5))) exposure. In 2006, the authors conducted a panel study to investigate directly whether vascular function and inflammation (assessed by C-reactive protein) modify PM(2.5)-associated reductions in heart rate variability among 23 young male workers (mean age, 40 years) from Massachusetts. Concurrent 24-hour ambulatory electrocardiogram and personal PM(2.5) exposure information was collected over a total of 36 person-days, including either or both welding and nonwelding days. Linear mixed models were used to examine the 5-minute standard deviation of normal-to-normal intervals (SDNN) in relation to the moving PM(2.5) averages in the preceding 1-4 hours. C-reactive protein levels and 3 measures of vascular function (augmentation index, mean arterial pressure, and pulse pressure) were determined at baseline. The authors observed an inverse association between the 1-hour PM(2.5) and 5-minute SDNN. Greater SDNN declines were observed among those with C-reactive protein (P(interaction) < 0.001) and augmentation index (P = 0.06) values at or above the 75th percentile and pulse pressure values below the 75th percentile (P < 0.001). Systemic inflammation and poorer vascular function appear to aggravate particle-related declines in heart rate variability among workers.
Biodynamics; Biological-effects; Biological-factors; Biological-function; Biological-monitoring; Biological-systems; Blood-vessels; Cardiovascular-function; Cardiovascular-system; Cardiovascular-system-disorders; Heart-rate; Medical-care; Medical-monitoring; Particle-aerodynamics; Particulates; Physical-reactions; Physiological-effects; Physiological-factors; Physiological-function; Physiological-measurements; Physiological-response; Psychological-factors; Psychological-reactions; Psychological-responses; Risk-factors; Veins; Welders; Welding-industry; Work-environment; Work-performance; Worker-health; Workplace-studies;
Author Keywords: augmentation; C-reactive protein; disease susceptibility; heart rate; inflammation; particulate matter; vascular diseases; welding
Dr. Shona C. Fang, Harvard School of Public Health, 665 Huntington Avenue, Building 1, Room 1402, Boston, MA 02115
American Journal of Epidemiology
Harvard School of Public Health