Neurologic illness associated with occupational exposure to the solvent 1-bromopropane - New Jersey and Pennsylvania, 2007-2008.
Perrone J; Marcus SM; Blando JD; Schill DP; Trout DB; Schulte PA; Geraci CL; Dotson GS; Hanley KW; Mead KR; Myers DVL; Curran C
MMWR 2008 Dec; 57(48):1300-1302
1-Bromopropane (1-BP) (n-propyl bromide) is a solvent increasingly used as a substitute for ozone-depleting chloro-fluorocarbons and similar regulated compounds. 1-BP is used in vapor and immersion degreasing operations and other manufacturing processes, and as a solvent in industries using aerosol-applied adhesives. In some states, 1-BP is used as a solvent in dry cleaning because of restrictions on use of perchloroethylene (tetrachloroethylene), a possible human carcinogen. Published studies of workers exposed to 1-BP have raised concerns about occupational health risks associated with exposure. This report describes two cases involving workers exposed to 1-BP and diagnosed with clinical manifestations of neurotoxicity. The cases, when coupled with previously reported studies of workers exposed to 1-BP, illustrate potential health risks of 1-BP exposure. Clinicians and public health professionals should be alert to potential health effects among workers exposed to 1-BP, particularly in dry cleaning and other workplaces where 1-BP use might be increasing, and effective control methods to limit exposure to 1-BP should be implemented at worksites. Both cases involved neurotoxic effects that likely resulted from occupational exposure to 1-BP in the electronics and dry cleaning industries. The cases were reported to regional poison control centers in Pennsylvania (2007) and New Jersey (2008) by attending physicians who treated the affected workers. The cases were investigated by federal and state health agencies, and more in-depth investigations of the New Jersey case currently are being conducted by the New Jersey Department of Health and Senior Services and CDC.
Solvents; Solvent-vapor-degreasing; Solvent-vapors; Neurotoxicity; Neurotoxins; Neurotoxic-effects; Dry-cleaning-industry; Dry-cleaning-solvents; Electronics-industry
J. Perrone, MD, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
Journal Article; Trade
DSHEFS; DART; EID
Morbidity and Mortality Weekly Report