Urinary 8-isoprostane and 8-OHdG concentrations in boilermakers with welding exposure.
Nuernberg AM; Boyce PD; Cavallari JM; Fang SC; Eisen EA; Christiani DC
J Occup Environ Med 2008 Feb; 50(2):182-189
OBJECTIVE: To investigate the association of exposure to fine particulate matter (PM2.5) with DNA damage and oxidative stress in boilermakers exposed to welding fumes. METHODS: Forty-one workers were monitored over 24 hours during which baseline, postshift, bedtime, and next morning measurements were collected. Twenty-two workers participated as controls. RESULTS: Linear regression was used to model pairwise change in u-8-isoprostane and u-8-OHdG: pre- to postshift, preshift to bedtime, postshift to bedtime, and postshift to next morning. In the models, pre- to postshift change in 8-OHdG was statistically significant, whereas postshift to bedtime change in 8-isoprostane showed an unexpected inverse relationship with PM2.5. CONCLUSIONS: Acute welding exposure is associated with a postshift blunting of systemic inflammation in chronically exposed boilermakers, as measured by 8-isoprostane. The level of oxidative DNA damage as measured by 8-OHdG is less clear.
Welders; Welding-industry; DNA-damage; Fumes; Statistical-analysis; Oxidative-metabolism; Urinalysis; Occupational-exposure; Particle-aerodynamics; Particulates
David Christiani, MD, MPH, MS, Department of Environmental Health, Harvard School of Public Health, Massachusetts General Hospital/Harvard Medical School, 665 Huntington Avenue, Building 1, Room 1407, Boston, MA 02115
Journal of Occupational and Environmental Medicine
Harvard School of Public Health