Ah receptor: xenobiotic response meets inflammation.
Blood 2008 Aug; 112(4):928-929
AhR mediates a broad range of biological responses to environmental chemicals, including suppression of immune functions. In this issue of Blood, Lawrence and colleagues demonstrate that AhR is responsible for the anti-inflammatory activity of new antiallergic drug candidates, likely by blocking dendritic-cell function to generate proinflammatory T-helper cells.
Biological-effects; Biological-monitoring; Biological-systems; Environmental-exposure; Environmental-hazards; Cell-biology; Cell-function; Cellular-function; Cellular-reactions; Chemical-hypersensitivity; Chemical-properties; Allergic-reactions; Drug-receptor; Drugs; Immune-system; Immunochemistry
Health Effects Laboratory Division, CDC National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV, 26505