Pulmonary surfactant interactions with respirable particles.
Proceedings of the 3rd Symposium on Respirable Dust in the Mineral Industries, Pittsburgh, Pennsylvania, October 17-19, 1990. Frantz RL, Ramani, RV, eds., Littleton, CO: Society for Mining, Metallurgy, and Exploration, 1990 Oct; :127-130
This review summarizes three sets of ongoing studies which we are performing in collaboration with a number of researchers associated with the Dept. of Interior - Generic Mineral Technology Center for the Study of Respirable Dusts, concerning surfactant-particle interactions studied using this surrogate surfactant. These topics are: (A) the suppression of mineral particle cytotoxic potential by DPL adsorption and the persistence of this effect under conditions of enzymatic digestion; (B) surfactant suppression of organic particle cytotoxicity by DPL adsorption and the effect on subsequent expression of genotoxic potential; (C) potential effects of surfactant on heterogeneous structured complex respirable particles. The references list some of our reports which can provide additional information on these studies. Further, those reports provide reference, to the literature of the field and to the work, of others on these topics, Deep lung airspaces, the pulmonary alveoli and respiratory bronchiole, are coated with a hypophase which is rich in surfactant biomolecule secreted by the alveolar type II epithelial cell. The surfactant is known to be critical to maintaining stable low surface tension on the inner surfaces of the alveoli by forming a surfactant layer on the air-liquid interface of the alveolar hypophase. Upon deposition in the acinar regions of the lung a respired particle's initial contact will be with this surfactant coating over pulmonary tissue. A primary component of this surfactant is the phospholipid diacyl glyceropholphorylcholine, commonly called lecithin. A surface layer of dipalmitoyl lecithin on saline will act much as full pulmonary surfactant in decreasing surface tension and producing a hysteresis in surface tension behavior with surface area. We have used dipalmitoyl glyceropholphorylcholine, or dipalmitoyl lecithin (DPL), a major component of that surfactant, dispersed in physiologic saline a, a surrogate for studying interaction, of both mineral and organic respirable particle, with pulmonary surfactant and consequent effect on particle toxic behavior.
Silica-dusts; Quartz-dust; Exposure-assessment; Dust-particles; Dust-exposure; Airborne-particles; Airborne-dusts; Particulate-dust; Pulmonary-system-disorders; Respiratory-system-disorders; Respiratory-irritants; Lung-disease; Lung-irritants; Fibrous-dusts; Surfactants; Silicosis; Silicon-compounds; Silicates
Proceedings of the 3rd Symposium on Respirable Dust in the Mineral Industries, Pittsburgh, Pennsylvania, October 17-19, 1990