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Pulmonary surfactant adsorption and the expression of silica toxicity.

Authors
Keane-MJ; Wallace-WE
Source
Silica and silica-induced lung diseases. Castranova V, Vallyathan V, Wallace WE, eds. Boca Raton, FL: CRC Press, 1995 Dec; :271-281
Link
NIOSHTIC No.
20034307
Abstract
In the alveolar regions of the lung, the interface between the epithelial cells and the air within alveoli consists of an aqueous dispersion of materials collectively designated pulmonary surfactant. Particles of silica or any other material that are inhaled into this region do not directly contact cells or tissue; the first contact will be with the hypophase that forms the tissue/air interface. Thus, interaction with the surfactant must precede any physical or chemical surface interaction with lung cells.
Keywords
Silica-dusts; Quartz-dust; Exposure-assessment; Dust-particles; Dust-exposure; Airborne-particles; Airborne-dusts; Particulate-dust; Pulmonary-system-disorders; Respiratory-system-disorders; Respiratory-irritants; Lung-disease; Lung-irritants; Fibrosis; Fibrous-dusts; Surfactants; Silicosis; Silicon-compounds; Silicates; Adsorbents; Breathing
CAS No.
14808-60-7
Publication Date
19951220
Document Type
Chapter
Editors
Castranova-V; Vallyathan-V; Wallace-WE
Fiscal Year
1996
ISBN No.
9780849347092
NIOSH Division
DRDS
Source Name
Silica and silica-induced lung diseases
State
WV
Page last reviewed: April 12, 2019
Content source: National Institute for Occupational Safety and Health Education and Information Division