Pulmonary surfactant adsorption and the expression of silica toxicity.
Silica and silica-induced lung diseases. Castranova V, Vallyathan V, Wallace WE, eds. Boca Raton, FL: CRC Press, 1995 Dec; :271-281
In the alveolar regions of the lung, the interface between the epithelial cells and the air within alveoli consists of an aqueous dispersion of materials collectively designated pulmonary surfactant. Particles of silica or any other material that are inhaled into this region do not directly contact cells or tissue; the first contact will be with the hypophase that forms the tissue/air interface. Thus, interaction with the surfactant must precede any physical or chemical surface interaction with lung cells.
Silica-dusts; Quartz-dust; Exposure-assessment; Dust-particles; Dust-exposure; Airborne-particles; Airborne-dusts; Particulate-dust; Pulmonary-system-disorders; Respiratory-system-disorders; Respiratory-irritants; Lung-disease; Lung-irritants; Fibrosis; Fibrous-dusts; Surfactants; Silicosis; Silicon-compounds; Silicates; Adsorbents; Breathing
Castranova-V; Vallyathan-V; Wallace-WE
Silica and silica-induced lung diseases