NIOSHTIC-2 Publications Search

Nanomaterial labels in electrochemical immunosensors and immunoassays.

Liu-G; Lin-Y

Talanta 2007 Dec; 74(3):308-317

http://dx.doi.org/10.1016/j.talanta.2007.10.014

20034119

This article reviews recent advances in nanomaterial labels in electrochemical immunosensors and immunoassays. Various nanomaterial labels are discussed, including colloidal gold/silver, semiconductor nanoparticles, and markers loaded nanocarriers (carbon nanotubes, apoferritin, silica nanoparticles, and liposome beads). The enormous signal enhancement associated with the use of nanomaterial labels and with the formation of nanomaterial-antibody-antigen assemblies provides the basis for ultrasensitive electrochemical detection of disease-related protein biomarkers, biothreat agents, or infectious agents. In general, all endeavors cited here are geared to achieve one or more of the following goals: signal amplification by several orders of magnitude, lower detection limits, and detecting multiple targets.

Electrochemical-properties; Electrochemical-reactions; Electrochemistry; Particle-counters; Particulate-sampling-methods; Particulates; Immunochemistry; Immune-reaction; Biomarkers; Biological-agents; Biological-effects; Biological-factors; Biological-function; Biological-monitoring; Biological-systems; Nanotechnology; Author Keywords: Nanomaterials; Nanoparticles; Immunosensors; Immunoassays; Carbon Nanotubes; Biomarkers

Guodong Liu, Department of Chemistry and Molecular Biology, North Dakota State University, Fargo, ND 58105-5516

TLNTA2

7440-44-0

20071215

Journal Article

guodong.liu@ndsu.edu

Grant

2008

Grant-Number-R01-OH-008173

3

0039-9140

Agriculture, Forestry and Fishing

Talanta

WA; ND

Battelle Pacific Northwest Laboratories