Association of cytokine gene polymorphisms with rate of decline in lung function.
Yucesoy B; Kurzius-Spencer M; Johnson VJ; Fluharty K; Kashon ML; Guerra S; Luster MI; Burgess JL
J Occup Environ Med 2008 Jun; 50(8):642-648
Objective: To investigate whether genetic variants involved in cytokine expression are associated with the age-related rate of decline in forced expiratory volume in 1 second (FEV1). Methods: Functional polymorphisms in the TNF[alpha], TGF[beta]1, IL-1[beta], IL-1RN, IL-13, and IL-8 genes were investigated in 374 active firefighters with at least five pulmonary function tests. Results: A protective effect was found between the presence of the TGF[beta]1 -509 TT genotype and rate of decline in FEV1 (P = 0.043). Carrying an A allele at TNF[alpha] -308 (P = 0.010) and GG genotype at TNF[alpha] -238 (P = 0.028) was associated with a more rapid rate of FEV1 decline. The TNF[alpha] -308A/-238G haplotype was also associated with an increased rate of decline as compared with the other haplotypes. Conclusions: Interindividual variability in progressive decline in FEV1 may be explained in part by genetic variations within genes involved in inflammatory responses.
Genes; Lung-function; Lung-disease; Lung-disorders; Diseases; Lung-function; Pulmonary-system-disorders; Respiratory-system-disorders
Berran Yucesoy, PhD, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505-2888
Journal of Occupational and Environmental Medicine