Occupational risks for idiopathic pulmonary fibrosis mortality in the United States.
Pinheiro GA; Antão VC; Wood JM; Wassell JT
Int J Occup Environ Health 2008 Apr-Jun; 14(2):117-123
Metal and wood dust exposures have been identified as possible occupational risk factors for idiopathic pulmonary fibrosis (IPF). We analyzed mortality data using ICD-10 code J84.1-"Other interstitial pulmonary diseases with fibrosis," derived age-adjusted mortality rates for 1999-2003, and assessed occupational risks for 1999, by calculating proportionate mortality ratios (PMRs) and mortality odds ratios (MORs) using a matched case-control approach. We identified 84,010 IPF deaths, with an age-adjusted mortality rate of 75.7 deaths/million. Mortality rates were highest among males, whites, and those aged 85 and older. Three industry categories with potential occupational exposures recognized as risk factors for IPF were identified: "Wood buildings and mobile homes" (PMR = 4.5, 95% confidence interval (CI) 1.2-11.6 and MOR = 5.3, 95% CI 1.2-23.8), "Metal mining" (PMR = 2.4, 95% CI 1.3-4.0 and MOR = 2.2, 95% CI 1.1-4.4), and "Fabricated structural metal products" (PMR = 1.9, 95% CI 1.1-3.1 and MOR = 1.7, 95% CI 1.0-3.1). Workers in these industry categories may benefit from toxicological studies and improved surveillance for this disease.
Aerosol-particles; Exposure-assessment; Exposure-levels; Exposure-limits; Alveolar-cells; Dust-exposure; Cell-damage; Cell-cultures; Particulate-dust; Wood; Wood-dusts; Woodworkers; Woodworking-industry; Pulmonary-congestion; Pulmonary-disorders; Pulmonary-system; Pulmonary-system-disorders; Breathing; Breathing-zone; Statistical-analysis; Age-factors; Age-groups; Surveillance-programs;
Author Keywords: idiopathic pulmonary fibrosis; mortality data; industrial hazards
Germania A. Pinheiro, NIOSH, DRDS, 1095 Willowdale Rd, MS 1811, Morgantown, WV 26505
Healthcare and Social Assistance; Manufacturing; Construction
International Journal of Occupational and Environmental Health