Regulation of vascular reactivity in scleroderma: new insights into Raynaud's phenomenon.
Rheum Dis Clin North Am 2008 Feb; 34(1):81-87
Because of the role of the RhoA/Rho kinase (ROCK) pathway in regulating numerous pathologic processes including vasoconstriction, vascular remodeling, and fibrosis, ROCK inhibitors may be especially beneficial in treating Raynaud's phenomenon and scleroderma.
Muscle-cells; Proteins; Enzymes; Hormone-activity; Hormones; Vasoactive-agents; Blood-vessels; Skin-exposure; Skin-protection; Vibration-disease
Nicholas A. Flavahan PhD, Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Ross Research Building R370, 720 Rutland Avenue, Baltimore, MD 21205
Rheumatic Diseases Clinics of North America
Jonhs Hopkins University