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Architecture and cellular composition of the air-blood barrier.

Authors
Pinkerton-KE; Gehr-P; Crapo-JD
Source
Treatise on Pulmonary Toxicology. Comparative Biology of the Normal Lung. Boca Raton. FL: CRC Press, 1992 Feb; 1:121-128
Link
NIOSHTIC No.
20033783
Abstract
There are over 4000 different varieties of mammals. Among the terrestrial mammals, body size ranges from the 2-g shrew to the 6600-kg elephant. Lung tissue mass involved in gas exchange in this class of animal , also covers a wide spectrum. Differences in the dimensions of the mammalian respiratory system are intriguing, since those pulmonary tissues involved in gas exchange are strikingly similar in organization and cellular composition, yet serve vastly different oxygen consumption needs in a highly efficient manner for animals spanning more than a three million-fold difference in total body mass (Gehr et aI., 1981). The purpose of this chapter is to review and to compare the anatomy and cellular composition of the alveolar region in mammalian lungs.
Keywords
Respiratory-function-tests; Respiratory-gas-analysis; Respiratory-hypersensitivity; Respiratory-irritants; Respiratory-rate; Respiratory-system-disorders; Animal-studies; Animals; Cellular-function; Cellular-reactions; Cellular-respiration; Cellular-structures; Lung-burden; Lung-cells; Lung-disorders; Lung-function; Lung-irritants; Alveolar-cells; Airborne-dusts; Airborne-fibers
Contact
K. E. Pinkerton, Department of Anatomy School of Veterinary Medicine University of California, Davis, CA 95616-8542
Publication Date
19920201
Document Type
Chapter
Funding Amount
1055222
Funding Type
Cooperative Agreement
Fiscal Year
1992
ISBN No.
9780849388392
Identifying No.
Cooperative-Agreement-Number-U07-CCU-906162
Source Name
Treatise on Pulmonary Toxicology. Comparative Biology of the Normal Lung
State
CA; NC
Performing Organization
University of California - Davis
Page last reviewed: November 8, 2019
Content source: National Institute for Occupational Safety and Health Education and Information Division