In vitro genotoxicity of particulate and semi-volatile organic compound exhaust materials from a set of gasoline and a set of diesel engine vehicles operated at 30 degrees F.
Ensell-M; Keane-M; Ong-T; Wallace-W
Proceedings of the 9th Diesel Engine Emission Reduction (DEER) Conference, August 24-28, 2003, Newport, Rhode Island. Washington, DC: Department of Energy, 2003 Aug; :1-58
Conclusions and Directions: 1. Diesel and gasoline engine exhaust particulate can contain genotoxic compounds. 2. DEP genotoxicant content is affected by fuel, engine operating condition. 3. DEP can express genotoxic activity in vitro under conditions modeling soot deposition in the lung. 4. Biologically-available genotoxicant activity of engine exhaust particulate can be assayed in short-term tests in a physiologically-plausible manner. 5. Correlation can be sought with fuel, engine design and operation parameters. 6. The help evaluate and guide the development of duels, engine design, and emission controls.
Diesel-emissions; Diesel-engines; Diesel-exhausts; Fuels; Exhaust-gases; Genotoxic-effects; Genotoxicity; Gene-mutation; Particulates; Airborne-particles; Aerosols; Aerosol-particles
William Wallace, National Institute for Occupational Safety and Health, 1095 Willowdale Rd., Morgantown, WV 26505
Proceedings of the 9th Diesel Engine Emission Reduction (DEER) Conference, August 24-28, 2003, Newport, Rhode Island