Lymph node silicosis and pulmonary silicosis: an autopsy study.
Ducatman-B; Cox-Ganser-J; Stead-J; Maymind-M; Saffiotti-U
Lab Invest 2001 Jan; 81(1):6a
Background: Lymph node silicosis (LS) may increase the likelihood of parenchymal silicosis (PS). During a pilot study on lung cancer and silicosis, using autopsy tissue and exposure data from German uranium miners, we investigated this hypothesis. Design: from a large East German autopsy archive, 1957-1992, we selected 302 former uranium miners: 205 cases of presumed lung cancer and 97 cases dying of other causes. Autopsy slides on 292 cases were reviewed by 4 pathologists; 251 were graded for LS and PS by at least two pathologists. Estimates of silica exposure (Si-Exp) were available for all. In a multi-variable logistic analysis model, the presence of lymph node silicosis was highly significant for the outcome of PS with a substantial odds ratio of 7. Conclusion: In our autopsy cross-sectional analysis study, the majority of PS cases (88%) also had LS. Those cases or LS alone had lower cumulative silica exposures than those cases with a combination of LS and PS. These data support the hypothesis that LS may precede PS.
Chemical-reactions; Chemical-synthesis; Silicate-miners; Silicosis; Chemical-hypersensitivity; Chemical-properties; Chemical-synthesis; Lung-cells; Lung-cancer; Lung; Pulmonary-disorders; Epidemiology; Statistical-analysis
Abstract; Conference/Symposia Proceedings